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Sarah Armstrong, a member of the AAP guideline committee, stated in a 2023 AAP press briefing: "We do not have the evidence to support pharmacotherapy with GLP-1 agonists below age 12, and clinicians should not extrapolate from adolescent data to younger children without trial-level safety evidence." The Endocrine Society's pediatric obesity guideline similarly restricts pharmacotherapy recommendations to adolescents aged 12 and older when lifestyle interventions have been insufficient [7]

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Schizophrenia Long-term use (up to 24 weeks) of 10003600 mg/day helped reduce negative symptoms (like low motivation, withdrawal)[1]

Sepsis is known to impair pro-inflammatory immune response and increase some inflammatory and oxidative biomarkers in blood that spread throughout the world and is a major concern in ICU which has a significant mortality